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RARB

Basics

Aliases:
This biomarker is also known as:
  • NR1B2,
  • HAP,
  • RRB2,
  • Nuclear receptor subfamily 1 group B member 2,
  • retinoic acid receptor, beta,
  • RAR-beta,
  • retinoic acid receptor beta variant 1,
  • hepatitis B virus activated protein,
  • retinoic acid receptor beta 4,
  • retinoic acid receptor beta,
  • HBV-activated protein,
  • RAR-epsilon,
  • retinoic acid receptor beta variant 2,
  • retinoic acid receptor beta 5,
  • retinoic acid receptor beta 2,
  • retinoic acid receptor, beta polypeptide,

View in BioMuta

Description…

The RARB gene encodes the retinoic acid receptor beta. It is a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators (NRB1 class). These receptors bind to their targets as heterodimers in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. This receptor localizes to the cytoplasm and to subnuclear compartments where it binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that the RARB protein limits growth of many cell types by regulating gene expression. There are three distinct RAR subtypes; RARalpha, RARbeta and RARgamma. RARalpha is present in most tissue types, whereas RARbeta and RARgamma expression is more selective. Two full length transcript variants have been verified. A third is possible.

Attributes

QA State: Under Review
Type: Gene
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.

Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html