Aliases:This biomarker is also known as:
- atypical protein kinase C-lambda/iota,
- protein kinase C, iota,
- EC 220.127.116.11,
- Atypical protein kinase C-lambda/iota,
- protein kinase C iota type,
PRKCI is a member of the protein kinase C (PKC) family of serine/threonine protein kinases. It is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis.
|QA State:||Under Review|
There are no datasets associated with this biomarker.