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POLR2L

Basics

Aliases:
This biomarker is also known as:
  • RNA polymerase II 7.6 kDa subunit,
  • polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa,
  • RNA polymerases I, II, and III subunit ABC5,
  • DNA-directed RNA polymerases I, II, and III subunit RPABC5,
  • RPB10 homolog,
  • RPB10beta,
  • hsRPB10b,
  • RPABC5,
  • RBP10,
  • RPB10,
  • polymerase (RNA) II (DNA directed) polypeptide L (7.6kD),
  • hRPB7.6,
  • RPB7.6,
  • DNA-directed RNA polymerase III subunit L,

View in BioMuta

Description…

POLR2L is the central component of RNA polymerase II. RNA polymerase II is the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit may be shared by the other two DNA-directed RNA polymerases, I and III. RNA polymerases, or Pols, are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is thought to be part of the core element with the central large cleft.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

No additional breast data available.

Performance Comment

POLR2L was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html