pleiotrophin
Basics
Aliases:
This biomarker is also known as:- HBNF-1,
- HBGF-8,
- HARP,
- heparin binding growth factor 8,
- HBGF8,
- pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1),
- HBNF1,
- Heparin-binding brain mitogen,
- heparin-binding brain mitogen,
- Osteoblast-specific factor 1,
- OSF-1,
- heparin-binding growth factor 8,
- PTN,
- osteoblast-specific factor 1,
- Heparin-binding growth factor 8,
- HB-GAM,
- neurite growth-promoting factor 1,
- Heparin-binding neurite outgrowth-promoting factor 1,
- heparin-binding growth-associated molecule,
- NEGF1,
- HBBM,
- heparin-binding neurite outgrowth-promoting factor 1,
- HBNF,
- heparin affin regulatory protein,
- Heparin-binding growth-associated molecule,
Description…
Pleiotrophin, or PTN, is a secreted growth factor found in osteoblasts and brain tissue. PTN induces neurite outgrowth and is mitogenic for fibroblasts, epithelial, and endothelial cells. It binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.
Attributes
| QA State: | Under Review |
|---|---|
| Type: | Protein |
| Short Name: |
Datasets
There are no datasets associated with this biomarker.
Organs
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Resources
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
