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PCA3

Basics

Aliases:
This biomarker is also known as:
  • PCAT3,
  • prostate cancer antigen 3 (non-protein coding),
  • prostate cancer associated transcript 3 (non-protein coding),
  • prostate cancer antigen 3,
  • DD3,
  • non-protein coding RNA 19,
  • NCRNA00019,

View in BioMuta

Description…

The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. Because there is no extensive open reading frame, the gene is thought to express a noncoding RNA. The FDA has approved an assay for prostate cancer that uses the ratio of PCA3 RNA to PSA RNA in urine. The assay is used to help physicians determine the need for repeat prostate biopsies in men 50 years of age or older who have had a previous negative biopsy. When used in conjunction with other clinical information, the use of this test can reduce the need for unnecessary prostate biopsies.

Attributes

QA State: Curated
Type: Gene
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: Three
QA State: Curated

Overview

The prostate cancer antigen 3 (PCA3) gene is a highly specific biomarker upregulated in prostate cancer. The PCA3 gene (prostate cancer antigen 3) is a non-coding gene that is over-expressed in prostate cancer. PCA3 in conjunction with other clinical tools has been shown to be as effective as the PSA (prostate specific antigen) assay in predicting the presence of prostate cancer. The FDA recently approved the first molecular test that uses PCA3 to help determine the need for repeat prostate biopsies in men who have had a previous negative biopsy.

Performance Comment

The FDA has approved an assay for prostate cancer that uses the ratio of PCA3 RNA to PSA RNA in urine. The assay is used to help physicians determine the need for repeat prostate biopsies in men 50 years of age or older who have had a previous negative biopsy. When used in conjunction with other clinical information, the use of this test can reduce the need for unnecessary prostate biopsies.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html