Description…

CDKN2A locus gives rise to 2 distinct transcripts from different promoters: p16 (INK4A) and p14 (ARF). Each has a 5-prime exon which is spliced into common exons 2 and 3 but in some sequences in a different reading frame. The beta transcript of CDKN2A encodes p14(ARF). P14/ARF has the ability to elicit a p53 response, which results in increased expression of both CDKN1A, also called CIP1, and MDM2, resulting in a cell cycle arrest in both the G1 and G2/M phases. p14/ARF binds to MDM2 and promotes the rapid degradation of MDM2. The deletion of the ARF-INK4A locus simultaneously impairs the INK4A--cyclin D/CDK4--RB and the ARF--MDM2--p53 pathways.

Datasets

There are no datasets associated with this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.