Aliases:This biomarker is also known as:
- Transcription factor p64,
- v-myc avian myelocytomatosis viral oncogene homolog,
- Proto-oncogene c-Myc,
- Myc proto-oncogene protein,
- v-myc myelocytomatosis viral oncogene homolog (avian),
- myc-related translation/localization regulatory factor,
- avian myelocytomatosis viral oncogene homolog,
- Class E basic helix-loop-helix protein 39,
- myc proto-oncogene protein,
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It participates in the regulation of gene transcription of specific target genes. MYC binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of the MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Evidence shows that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini.
|QA State:||Under Review|
There are no datasets associated with this biomarker.