MYC
Basics
Aliases:
This biomarker is also known as:- Transcription factor p64,
- BHLHE39,
- v-myc avian myelocytomatosis viral oncogene homolog,
- Proto-oncogene c-Myc,
- Myc proto-oncogene protein,
- c-Myc,
- v-myc myelocytomatosis viral oncogene homolog (avian),
- myc-related translation/localization regulatory factor,
- avian myelocytomatosis viral oncogene homolog,
- MRTL,
- Class E basic helix-loop-helix protein 39,
- bHLHe39,
- myc proto-oncogene protein,
Description…
MYC is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It participates in the regulation of gene transcription of specific target genes. MYC binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Mutations, overexpression, rearrangement and translocation of the MYC gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. Evidence shows that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini.
Attributes
| QA State: | Under Review |
|---|---|
| Type: | Gene |
| Short Name: |
Datasets
There are no datasets associated with this biomarker.
Organs
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Studies
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Publications
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
Resources
This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.
