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Meltzer 3-marker panel for Esophageal Adenocarcinoma

Basics

Attributes

QA State: Under Review
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Using real-time quantitative methylation-specific PCR, ten genes (HPP1, RUNX3, RIZ1, CRBP1, 3-OST-2, APC, TIMP3, p16, MGMT and p14) were screened for promoter hypermethylation in 77 esophageal adenocarcinoma, 93 Barrett's Esophagus, and 64 normal esophagus specimens. p16, RUNX3 and HPP1 displayed increasing methylation frequencies in Barrett's Esophagus vs. esophageal adenocarcinoma samples, with the increases in methylation occurring early, at the interface between Barrett's Esophagus and low-grade dysplasia. Further study has shown that hypermethylation of p16 and HPP1 are independently associated with an increased risk of progression. In combined analyses, risk was detectable up to, but not earlier than, two years prededing neoplastic progression. Hypermethylation of p16, RUNX3 and HPP1 in Barrett's Esophagus or low-grade dysplasia may represent independent risk factors for the progression of Barrett's Esophagus to high-grade dysplasia or esophageal adenocarcinoma.

Panel Details

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement