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Meltzer 3-marker panel for Esophageal Adenocarcinoma

Basics

Attributes

QA State: Under Review
Short Name:

Using real-time quantitative methylation-specific PCR, ten genes (HPP1, RUNX3, RIZ1, CRBP1, 3-OST-2, APC, TIMP3, p16, MGMT and p14) were screened for promoter hypermethylation in 77 esophageal adenocarcinoma, 93 Barrett's Esophagus, and 64 normal esophagus specimens. p16, RUNX3 and HPP1 displayed increasing methylation frequencies in Barrett's Esophagus vs. esophageal adenocarcinoma samples, with the increases in methylation occurring early, at the interface between Barrett's Esophagus and low-grade dysplasia. Further study has shown that hypermethylation of p16 and HPP1 are independently associated with an increased risk of progression. In combined analyses, risk was detectable up to, but not earlier than, two years prededing neoplastic progression. Hypermethylation of p16, RUNX3 and HPP1 in Barrett's Esophagus or low-grade dysplasia may represent independent risk factors for the progression of Barrett's Esophagus to high-grade dysplasia or esophageal adenocarcinoma.

Panel Details

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.

Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html