Aliases:This biomarker is also known as:
- obese, mouse, homolog of,
- leptin (murine obesity homolog),
- obesity factor,
- leptin (obesity homolog, mouse),
Leptin is secreted by white adipocytes and plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. Leptin has several endocrine functions and is also involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in the leptin gene and/or its regulatory regions cause severe obesity and morbid obesity with hypogonadism. The leptin gene has also been linked to type 2 diabetes mellitus development.
|QA State:||Under Review|
There are no datasets associated with this biomarker.