Aliases:This biomarker is also known as:
- Kirsten rat sarcoma-2 viral (v-Ki-ras2) oncogene homolog,
- transforming protein p21,
- oncogene KRAS2,
- PR310 c-K-ras oncogene,
- c-Kirsten-ras protein,
- v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog,
- cellular c-Ki-ras2 proto-oncogene,
- c-K-ras2 protein,
- K-ras p21 protein,
The KRAS gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region.
|QA State:||Under Review|
There are no datasets associated with this biomarker.