Aliases:This biomarker is also known as:
- Plasma kallikrein sensitive glycoprotein 120,
- ITI heavy chain H4,
- Inter-alpha-trypsin inhibitor family heavy chain-related protein,
- Inter-alpha-trypsin inhibitor heavy chain H4,
- Inter-alpha-inhibitor heavy chain 4,
The inter-alpha-trypsin inhibitors (ITI) are a family of plasma protease inhibitors, assembled from a light chain - bikunin, encoded by AMBP - and five homologous heavy chains (encoded by ITIH1, ITIH2, ITIH3, ITIH4, and ITIH5), contributing to extracellular matrix stability by covalent linkage to hyaluronan. ITIH4 is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of the ITIH4 gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene.
There are no datasets associated with this biomarker.