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IL8

Basics

Aliases:
This biomarker is also known as:
  • NAP-1,
  • interleukin-8,
  • C-X-C motif chemokine 8,
  • Emoctakin,
  • Neutrophil-activating protein 1,
  • MDNCF,
  • GCP1,
  • neutrophil-activating peptide 1,
  • T-cell chemotactic factor,
  • LECT,
  • IL-8,
  • small inducible cytokine subfamily B, member 8,
  • Granulocyte chemotactic protein,
  • NAF,
  • interleukin 8,
  • NAP1,
  • lymphocyte-derived neutrophil-activating factor,
  • LYNAP,
  • Monocyte-derived neutrophil-activating peptide,
  • chemokine (C-X-C motif) ligand 8,
  • GCP-1,
  • beta-thromboglobulin-like protein,
  • OTTHUMP00000199825,
  • MONAP,
  • Protein 3-10C,
  • AMCF-I,
  • 3-10C,
  • emoctakin,
  • LUCT,
  • T cell chemotactic factor,
  • CXCL8,

View in BioMuta

Description…

Interleukin 8 (IL8) is a member of the CXC chemokine family. This chemokine functions as a chemoattractant, or chemotactic factor, that attracts neutrophils, basophils, and T-cells, but not monocytes. IL8 is one of the major mediators of the inflammatory response, and is involved in neutrophil activation. It is released from several types of cells in response to an inflammatory stimulus. IL8 also functions as an angiogenic factor. The IL8 gene maps to chromosome 4q, and is found in a chemokine gene cluster along with ten other members of the CXC chemokine gene family. There are several N-terminal processed forms that are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. Among the forms are: IL-8(1-77), IL-8(5-77), IL-8(6-77), IL-8(7-77), IL-8(8-77), IL-8(9-77). IL-8(1-77) is generally referred to as interleukin 8. IL-8(6-77) is the most promiment form.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Two
QA State: Under Review

Overview

Performance Comment

Levels of IL8 in exhaled breath condensate indicated acute inflammation but were not indicative of lung cancer.

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

IL8 alone was not shown to be a strong predictor of ovarian cancer.

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

Performance Comment

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.

Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html