Aliases:This biomarker is also known as:
- Membrane glycoprotein 80,
- interleukin-6 receptor subunit alpha,
- interleukin 6 receptor alpha subunit,
- CD126 antigen,
- interleukin 6 receptor,
- IL-6R 1,
- IL-6R subunit alpha,
- IL-6 receptor subunit alpha,
The interleukin 6 receptor is a protein complex consisting of two parts: the IL6R (interleukin 6 receptor) subunit and the IL6ST (interleukin 6 signal transducer) subunit. The IL6R subunit binds to IL6 (interleukin 6) with low affinity, but does not transduce a signal. The IL6ST subunit is needed for signal activation. Impaired regulation of IL6 and IL6R have been linked to many diseases, such as multiple myeloma, autoimmune diseases, and prostate cancer. Isoforms encoded by alternatively spliced transcripts have been reported. Activation of the IL6/IL6R/IL6ST complex may lead to the regulation of the immune response, acute-phase reactions, and hematopoiesis.
|QA State:||Under Review|
There are no datasets associated with this biomarker.