Aliases:This biomarker is also known as:
- interleukin 2 receptor, alpha,
- IL-2R subunit alpha,
- IL-2 receptor subunit alpha,
- TAC antigen,
- interleukin-2 receptor subunit alpha,
- CD25 antigen,
The interleukin 2 receptor exists in three forms which differ in their ability to bind interleukin 2. The low affinity form of the receptor is a monomer of IL2RA, the alpha subunit. The alpha/beta subunit heterodimer, formed by IL2RA and IL2RB, is an intermediate affinity form. The alpha/beta/gamma heterotrimer formed by IL2RA, IL2RB, and IL2RG is the high affinity form. IL2RA is normally an integral membrane protein, although soluble IL2RA has been isolated. There are known alternately-spliced versions of IL2RA mRNAs, but their functions are unknown. Mutations in the IL2RA gene are associated with diabetes mellitus insulin-dependent type 10 (IDDM10). Complications of IDDM10 can adversely affect the eyes, kidneys, nerves, and blood vessels.
|QA State:||Under Review|
There are no datasets associated with this biomarker.