Aliases:This biomarker is also known as:
- interleukin 10,
- cytokine synthesis inhibitory factor,
- T-cell growth inhibitory factor,
Interleukin 10, a secreted protein belonging to the IL-10 family, is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. IL10 has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines (IL-2, IL-3, TNF and GM-CSF) produced by activated macrophages and by helper T-cells, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. IL10 is produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
|QA State:||Under Review|
There are no datasets associated with this biomarker.