Aliases:This biomarker is also known as:
- Isocitrate dehydrogenase [NADP] cytoplasmic,
- isocitrate dehydrogenase 1 (NADP+), soluble,
- Cytosolic NADP-isocitrate dehydrogenase,
- NADP(+)-specific ICDH,
- Oxalosuccinate decarboxylase,
IDH1 is an NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. IDH1 binds 1 magnesium or manganese ion per subunit. Defects in IDH1 are involved in the development of glioma.
|QA State:||Under Review|
There are no datasets associated with this biomarker.