Aliases:This biomarker is also known as:
- histone 1, H2aa,
- H2A histone family, member R,
- histone cluster 1, H2aa,
- Histone H2A/r,
- Histone H2A type 1-A,
HIST1H2AA, a member of the histone 2A family, is a core component of the nucleosome. The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (the octamer wraps approximately 147 bp of DNA). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. The HIST1H2AA gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element.
|QA State:||Under Review|
There are no datasets associated with this biomarker.