Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health


Personal tools

You are here: Home / Biomarkers / ERBB3



This biomarker is also known as:
  • Proto-oncogene-like protein c-ErbB-3,
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian),
  • EC,
  • p45-sErbB3,
  • p180-ErbB3,
  • LCCS2,
  • erbB3-S,
  • Tyrosine kinase-type cell surface receptor HER3,
  • HER3,
  • p85-sErbB3,
  • c-erbB-3,
  • proto-oncogene-like protein c-ErbB-3,
  • receptor tyrosine-protein kinase erbB-3,
  • lethal congenital contracture syndrome 2,
  • MDA-BF-1,
  • ErbB-3,
  • c-erbB3,
  • tyrosine kinase-type cell surface receptor HER3,

View in BioMuta


v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)


QA State: Curated
Type: Gene
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: One
QA State: Curated


No additional prostate data available.

Performance Comment

19 common probe sets (15 unique genes) were used to develop a PAM-based classifier, which had an average accuracy of 87% when it was tested on 47 independent tumor-adjacent stroma samples. The 15 genes represented in the classifier are: GADD45B, CDKN1A, NLRP1, ERBB3, FMO5, KIAA0746///SERINC2, AMFR, DPP4, PGC, YWHAE, EHF, TF, TNFSF10, EIF5A, TGM4. This is the first general tumor microenvironment-based prognostic classifier. Tumor-adjacent prostate cancer stroma contains numerous changes in gene expression at the time of diagnosis that correlate with the chance of relapse following prostatectomy. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for predicting outcomes for patients.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.