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This biomarker is also known as:
  • c-ErbB-2,
  • NEU,
  • Proto-oncogene c-ErbB-2,
  • MLN 19,
  • CD340,
  • Metastatic lymph node gene 19 protein,
  • CD_antigen=CD340,
  • p185erbB2,
  • TKR1,
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian),
  • HER-2,
  • HER2,
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),
  • Tyrosine kinase-type cell surface receptor HER2,
  • NGL,
  • MLN19,
  • Proto-oncogene Neu,
  • Receptor tyrosine-protein kinase erbB-2,
  • HER-2/neu,

View in BioMuta


ERBB2, often known as HER-2/neu, a single-pass type I membrane protein, is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It is part of several cell surface receptor complexes. ERBB2 has no ligand binding domain of its own, and needs a coreceptor for ligand binding. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele Ile654/Ile655. There are several transcript variants resulting from alternative splicing events. Some isoforms have not been fully characterized yet.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


Performance Comment



Phase: Two
QA State: Under Review


Amplification and/or overexpression of the ERBB2 gene has been reported in numerous cancers, including breast and ovarian tumors. Studies have suggested that ERBB2 overexpression represented a major negative prognostic indicator for patients with several human cancers, including endometrial carcinomas

Performance Comment

Despite many promising new markers for ovarian cancer, CA125 remains the single best biomarker in the phase II and phase III specimens tested in this study.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014

Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014

Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.