Aliases:This biomarker is also known as:
- MLN 19,
- v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian),
- Proto-oncogene c-ErbB-2,
- Metastatic lymph node gene 19 protein,
- Proto-oncogene Neu,
- v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog),
- Tyrosine kinase-type cell surface receptor HER2,
- Receptor tyrosine-protein kinase erbB-2,
ErbB2, a single-pass type I membrane protein, is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655. Amplification and/or overexpression of this gene has been reported in numerous cancers, including primary breast and ovarian tumors, as well as tumors from small bowel, esophagus, kidney and mouth. ErbB2 regulates outgrowth and stabilization of peripheral microtubules. Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.
|QA State:||Under Review|
There are no datasets associated with this biomarker.