Aliases:This biomarker is also known as:
- human type XVIII collagen,
- multi-functional protein MFP,
- antiangiogenic agent,
- collagen, type XVIII, alpha 1,
- Knobloch syndrome, type 1,
- collagen alpha-1(XVIII) chain,
COL18A1, also known as endostatin, is the alpha chain of type XVIII collagen. COL18A1 is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. COLA18A probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. It also inhibits endothelial cell proliferation and angiogenesis, and may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling.
|QA State:||Under Review|
There are no datasets associated with this biomarker.