Aliases:This biomarker is also known as:
- fibulin 3,
- Fibrillin-like protein,
- Extracellular protein S1-5,
- EGF containing fibulin-like extracellular matrix protein 1,
EFEMP1, also known as fibulin-3, binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. It may play a role in cell adhesion and migration, and may function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. EFEMP1 is up-regulated in malignant gliomas and may play a role in the agressive nature of these tumors by increasing glioma cell adhesiveness and invasive properties.
|QA State:||Under Review|
There are no datasets associated with this biomarker.