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Des-ubiquitin

Basics

Aliases:
This biomarker is also known as:
  • des-Gly-Gly-ubiquitin,

View in BioMuta

Description…

Des-ubiquitin is formed when a cysteine protease cleaves two carboxy-terminal glycine residues from ubiquitin.

Attributes

QA State: Curated
Type: Proteomic
Short Name:
HGNC Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: One
QA State: Under Review

Overview

Cathepsin B, which is a cysteine protease, cleaves 2 terminal glycine residues of ubiquitin generating des-ubiquitin. Both monomeric ubiquitin and des-ubiquitin corresponding to m/z values 8,565 and 8,451 are among the 9 candidates of the signature described in the Rahman 9-marker MALDI MS panel for Lung Cancer study.

Performance Comment

Des-ubiquitin belongs to a 9-member panel that provides a quantitative measure of the probability of having lung cancer that goes beyond the histological evaluation of preinvasive lesions. The identified members of the panel are TMSB4X (Thymosin beta-4), Ubiquitin, des-ubiquitin, ACBP, CSTA, Cytochrome C, and MIF.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

No associated publications found.

Resources

No associated resources found.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement