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DCP

Basics

Aliases:
This biomarker is also known as:
  • Prothrombin Induced by Vitamin K Absence II,
  • PIVKA II,
  • Des-gamma carboxyprothrombin,

View in BioMuta

Description…

Des-gamma-carboxy prothrombin (DCP) is a non-functional precursor of prothrombin. Prothrombin, produced by the liver, serves a critical role in normal hemostasis. Functional prothrombin contains several gamma-carboxy-glutamic acid (Gla) residues that are produced as the result of post-translational modification of glutamic acid residues mediated by vitamin K dependent gamma-glutamyl carboxylase. The formation of Gla residues can be impaired in patients with vitamin K deficiency or in patients receiving oral anticoagulant therapy. DCP lacks thrombotic activity and has been shown in multiple studies to be present in the serum of patients with HCC. DCP arises from an acquired defect in the post-translational carboxylation of the pro-thrombin precursor in malignant hepatocytes.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Liver

Attributes

Phase: Three
QA State: Curated

Overview

Hepatocellular carcinoma (HCC) is one of the most common solid malignancies worldwide, and its incidence in the United States is increasing. Despite advances in medical technology, the 5-year survival of patients with HCC improved minimally from 2% to 5% between 1981 and 1998. Since 90% of patients with HCC have underlying cirrhosis, patients with cirrhosis are candidates for HCC surveillance. The currently recommended surveillance tests for HCC are ultrasound evaluation of the liver (US), with or without measurement of serum alpha-fetoprotein (AFP). These tests are inadequately sensitive for use in screening, while ultrasound is also limited by the experience of the operator and on body habitus for adequate scanning. The performance of DCP to distinguish HCC from cirrhosis was compared to that of AFP or the lens culinaris agglutinin-reactive AFP (AFP-L3) and was shown to be superior, at a sensitivity of 92% and a specificity of 93%.

Performance Comment

The FDA has approved the use of DCP in a test designed to assess the risk of developing hepatocellular cancer (HCC) in patients with chronic liver disease. The test measures serum DCP levels, which can be used in conjunction with other clinical findings and imaging studies, to differentiate early HCC from cirrhosis.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html