Aliases:This biomarker is also known as:
- Tumor suppressor protein DCC,
- immunoglobulin superfamily DCC subclass member 1,
- colorectal tumor suppressor,
- Immunoglobulin superfamily DCC subclass member 1,
- immunoglobulin superfamily, DCC subclass, member 1,
- colorectal cancer suppressor,
- tumor suppressor protein DCC,
- deleted in colorectal cancer protein,
- netrin receptor DCC,
- Colorectal cancer suppressor,
- deleted in colorectal carcinoma,
DCC is a receptor for netrin 1, which is required for axon guidance. DCC is a transmembrane protein and a member of the immunoglobulin superfamily of cell adhesion molecules. It mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. The cytoplasmic tail of DCC interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
|QA State:||Under Review|
There are no datasets associated with this biomarker.