Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / CD59

CD59

Basics

Aliases:
This biomarker is also known as:
  • Protectin,
  • EJ16,
  • MEM43 antigen,
  • p18-20,
  • EL32,
  • CD59 glycoprotein,
  • CD59 antigen, complement regulatory protein,
  • MAC-IP,
  • HRF-20,
  • Membrane inhibitor of reactive lysis,
  • G344,
  • 1F5 antigen,
  • MACIF,
  • MIN1,
  • MIRL,
  • MIN3,
  • CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344),
  • MAC-inhibitory protein,
  • MIN2,
  • 16.3A5,
  • MIC11,
  • MSK21,
  • Membrane attack complex inhibition factor,
  • EJ30,
  • 20 kDa homologous restriction factor,

View in BioMuta

Description…

CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes, and several human cell lines. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific and is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.

Attributes

QA State: Under Review
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

Maintenance Notice: EDRN applications undergoing maintenance 2014-09-15 through the 16th. During this time, logins to this site will be unavailable.

Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html
Announcement