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This biomarker is also known as:
  • chemokine (C-C motif) ligand 2,
  • Monocyte chemoattractant protein 1,
  • MCP1,
  • Monocyte secretory protein JE,
  • monocyte chemoattractant protein-1,
  • HSMCR30,
  • small inducible cytokine subfamily A (Cys-Cys), member 2,
  • small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je),
  • monocyte chemotactic and activating factor,
  • SMC-CF,
  • monocyte chemoattractant protein 1,
  • Small-inducible cytokine A2,
  • MCP-1,
  • MGC9434,
  • Monocyte chemotactic and activating factor,
  • HC11,
  • monocyte chemotactic protein 1,
  • C-C motif chemokine 2,
  • small-inducible cytokine A2,
  • GDCF-2,
  • SCYA2,
  • monocyte secretory protein JE,
  • MCAF,
  • Monocyte chemotactic protein 1,

View in BioMuta


CCL2, also known as MCP-1, is a member of the chemokine superfamily. Chemokines are a family of small cytokines. The four chemokine subfamilies are based on the arrangement of N-terminal cysteine residues of the mature peptide. CCL2 is a member of the CC subfamily, characterized by two adjacent cysteine residues. CCL2 is a chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. CCL2 has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


No additional breast data available.

Performance Comment

CCL2, also known as MCP-1, was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.


The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014

Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014

Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.