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CADM1

Basics

Aliases:
This biomarker is also known as:
  • nectin-like 2,
  • IGSF4A,
  • MGC149785,
  • DKFZp686F1789,
  • BL2,
  • Synaptic cell adhesion molecule,
  • Necl-2,
  • sTSLC-1,
  • SYNCAM1,
  • sgIGSF,
  • NECL2,
  • immunoglobulin superfamily, member 4,
  • synCAM1,
  • IgSF4,
  • tumor suppressor in lung cancer 1,
  • cell adhesion molecule 1,
  • RA175,
  • Spermatogenic immunoglobulin superfamily,
  • Nectin-like protein 2,
  • TSLC1,
  • SYNCAM,
  • IGSF4,
  • MGC51880,
  • ST17,

View in BioMuta

Description…

CADM1, a single-pass type 1 cell membrane protein, appears to be involved in several biolotical processes: Apoptosis, Cell adhesion, Differentiation, Immunity and Spermatogenesis. CADM1 appears to mediate homophilic cell-cell adhesion in a Ca2+-independent manner. It may also mediate heterophilic cell-cell adhesion with CADM3 and PVRL3 in a Ca2+-independent manner. CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. It may additionally contribute to the less invasive phenotypes of lepidic growth tumor cells. In mast cells, CADM1 may mediate attachment to and promote communication with nerves. CADM1, together with MITF, is essential for development and survival of mast cells in vivo, and it may act as a synaptic cell adhesion molecule that drives synapse assembly. CADM1 may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. Finally, it may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa.

Attributes

QA State: Under Review
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html