Boeri miRNA signature of risk for lung cancer
miRNA expression analyses in plasma samples collected 1ÃƒÆ'Ã‚Â¢ÃƒÂ¢Ã¢â‚¬Å¡Ã‚Â¬ÃƒÂ¢Ã¢â€šÂ¬Ã…â€œ2 y before the onset of disease, at the time of CT detection and in disease-free smokers enrolled in the screening trial, resulted in the generation of miRNA signatures with strong predictive, diagnostic, and prognostic potential (area under the ROC curve ÃƒÆ'Ã‚Â¢ÃƒÂ¢Ã¢â€šÂ¬Ã‚Â°Ãƒâ€šÃ‚Â¥ 0.85). The signature of risk for lung cancer is comprised of 16 ratios composed from 15 miRNAs: 140-5p, 660, 320, 28-3p, 451, 92a, 197, 221, 19b, 142-3p, 15b, 30c, 30b, 17, 106a.
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This miRNA signature was able to identify the presence of aggressive lung cancer not only in tumor, but also in normal lung tissues and in plasma samples of patients. Moreover, miRNAs deregulated in plasma samples collected before clinical appearance of disease were powerful molecular predictors of high-risk disease development.
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