Aliases:This biomarker is also known as:
- Etk/Bmx cytosolic tyrosine kinase,
- EC 220.127.116.11,
- EC 2.7.10,
- BMX non-receptor tyrosine kinase,
- NTK38 tyrosine kinase,
- Bone marrow tyrosine kinase gene in chromosome X protein,
- Epithelial and endothelial tyrosine kinase,
- cytoplasmic tyrosine-protein kinase BMX,
BMX, or BMX non-receptor tyrosine kinase, belongs to the Tec kinase family. BMX, a non-receptor tyrosine kinase, plays a central but diverse modulatory role in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. The BMX protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified.
|QA State:||Under Review|
There are no datasets associated with this biomarker.