Aliases:This biomarker is also known as:
- F8/G253 antigen,
- Auberger B antigen,
- Basal cell adhesion molecule,
- Lutheran blood group glycoprotein,
- basal cell adhesion molecule (Lu and Au blood groups),
- basal cell adhesion molecule (Lutheran blood group),
- B-CAM cell surface glycoprotein,
- Lutheran blood group (Auberger b antigen included),
- Lutheran antigen,
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin alpha-5. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. It may also play a role in intracellular signalling. BCAM has wide tissue distribution (highest in the pancreas and very low in brain) and is closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls. Two transcript variants encoding different isoforms have been found for this gene.
|QA State:||Under Review|
There are no datasets associated with this biomarker.