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ARHGEF16

Basics

Aliases:
This biomarker is also known as:
  • NBR,
  • Rho guanine nucleotide exchange factor (GEF) 16,
  • ephexin-4,
  • Rho guanine exchange factor (GEF) 16,
  • GEF16,
  • Ephexin-4,
  • EPHEXIN4,
  • rho guanine nucleotide exchange factor 16,

View in BioMuta

Description…

ARHGEF16 is a guanine nucleotide exchange factor. Guanine nucleotide exchange factors regulate the activation of Rho-like GTPases. Guanidine exchange factors promote the GTP activation of Rho GTPase's by catalyzing the exchange of GDP for GTP.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

ARHGEF16 is a nucleotide exchange factor involved in regulating the activation of Rho-like GTPases. When the regulation occurs incorrectly, ARHGEF16 and other nucleotide exchange factors can aid malignant transformation.

Performance Comment

ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.

Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html