Aliases:This biomarker is also known as:
- apolipoprotein B (including Ag(x) antigen),
- Apo B-100,
- Apo B-48,
- Apolipoprotein B-100,
- Apolipoprotein B-48,
APOB, a secreted glycoprotein, is the main apolipoprotein of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). It occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-48 protein is produced after RNA editing of the apoB-100 transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. Mutations in this gene or its regulatory region cause hypobetalipoproteinemia, normotriglyceridemic hypobetalipoproteinemia, and hypercholesterolemia due to ligand-defective apoB, diseases affecting plasma cholesterol and apoB levels. APOB is up-regulated in response to enterovirus 71 (EV71) infection.
|QA State:||Under Review|
There are no datasets associated with this biomarker.