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ANO1

Basics

Aliases:
This biomarker is also known as:
  • anoctamin 1, calcium activated chloride channel,
  • TAOS2,
  • discovered on gastrointestinal stromal tumors protein 1,
  • transmembrane protein 16A,
  • Oral cancer overexpressed protein 2,
  • ORAOV2,
  • Transmembrane protein 16A,
  • anoctamin-1,
  • Tumor-amplified and overexpressed sequence 2,
  • tumor-amplified and overexpressed sequence 2,
  • transmembrane protein 16A (eight membrane-spanning domains),
  • FLJ10261,
  • DOG1,
  • TMEM16A,
  • Discovered on gastrointestinal stromal tumors protein 1,
  • oral cancer overexpressed 2,

View in BioMuta

Description…

ANO1, or anoctamin-1, is a calcium-activated chloride channel gene overexpressed in many tumors. ANO1 is ubiquitously expressed in epithelia and is thought to be important in epithelial fluid transport.

Attributes

QA State: Curated
Type: Protein
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

ANO1 is located within the 11q13 amplicon, one of the most frequently amplified chromosomal regions in human cancer. ANO1 is amplified and highly expressed in breast cancer cell lines and primary tumors.

Performance Comment

ANO1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html