Aliases:This biomarker is also known as:
- angiopoietin-like 3,
- Angiopoietin-like protein 3,
- angiopoietin-related protein 3,
- angiopoietin 5,
ANGPTL3, or angiopoietin-like 3, is a member of the angiopoietin-like family of secreted factors. It is a secreted protein expressed primarily in the liver, and also weakly expressed in the kidney. ANGPTL3 has the characteristic angiopoietin structure, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. ANGPTL3 is also thought to be involved in the regulation of angiogenesis.
|QA State:||Under Review|
There are no datasets associated with this biomarker.