Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / ACO1

ACO1

Basics

Aliases:
This biomarker is also known as:
  • IREB1,
  • citrate hydro-lyase,
  • ACONS,
  • IRP1,
  • cytoplasmic aconitate hydratase,
  • Aconitase,
  • ferritin repressor protein,
  • Iron-responsive element-binding protein 1,
  • iron regulatory protein 1,
  • aconitase 1, soluble,
  • IREBP1,
  • Ferritin repressor protein,
  • iron-responsive element binding protein 1,
  • Iron regulatory protein 1,
  • aconitate hydratase,
  • IREBP,
  • iron-responsive element-binding protein 1,
  • EC 4.2.1.3,
  • Citrate hydro-lyase,
  • IRE-BP 1,

View in BioMuta

Description…

aconitase 1, soluble

Attributes

QA State: Curated
Type: Gene
Short Name:

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Prostate

Attributes

Phase: One
QA State: Under Review

Overview

No additional prostate data available.

Performance Comment

This gene is part of a 114-gene set that comprises a stroma-specific classifier for nearby prostate tumors. Gene expression changes in stroma have been identified that can detect tumor nearby. This classifier predicted the tumor status of patients using tumor-free samples with an average accuracy of 97% (sensitivity = 98% and specificity = 88%) whereas classifiers trained with sets of 100 randomly generated genes had no diagnostic value. These results indicate that the prostate cancer microenvironment exhibits reproducible changes useful for categorizing the presence of tumor in patients when a prostate sample is derived from near the tumor but does not contain any recognizable tumor. (PMID:21459804)

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

No associated resources found.

News

The final report of the 2013 Cancer Biomarkers Bioinformatics Workshop is now available.

Announcement 06/26/2014


Please click here to register for the 9th EDRN Scientific Workshop from September 8-10, 2014, in Bethesda, Maryland. The meeting registration page also has agendas and hotel reservation information.
Announcement 06/05/2014


Funding Opportunity Available

Both RFAs for Molecular and Cellular Characterization of Screen-Detected Lesions have been published.

RFA-CA-14-010.html

and

RFA-CA-14-011.html