Aliases:This biomarker is also known as:
- Proto-Oncogene C-Yes,
- Proto-Oncogene Tyrosine-Protein Kinase YES,
- Tyrosine-Protein Kinase Yes,
- Cellular Yes-1 Protein,
- V-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1,
- Yamaguchi Sarcoma Oncogene,
YES1, also known as YES, is a non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. It is the cellular homolog of the Yamaguchi sarcoma virus oncogene and belongs to the src family of proteins. YES1 is involved in many phosphorylation reactions, including a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
YES has not been identified previously in serum as a lung cancer biomarker and represents a novel finding in the aptamer proteomic technology study (Ostroff et al, 2010). YES was observed up-regulated in lung cancer in this study.
YES is a member of a 12 protein panel that can discriminate NSCLC from controls with 91% sensitivity and 84% specificity in cross-validated training and 89% sensitivity and 83% specificity in a separate verification set, with similar performance for early and late stage NSCLC.