Aliases:This biomarker is also known as:
- X-ray repair cross-complementing protein 1,
- X-ray repair complementing defective repair in Chinese hamster cells 1,
- X-ray-repair, complementing defective, repair in Chinese hamster,
- DNA repair protein XRCC1,
XRCC1, or X-ray repair complementing defective repair in Chinese hamster cells 1, corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. XRCC1 interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3) to participate in the base excision repair pathway. It may be involved in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
|QA State:||Under Review|
There are no datasets associated with this biomarker.