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This biomarker is also known as:
  • X-box binding protein 1,
  • XBP-1,
  • XBP2,
  • TREB5,
  • Tax-responsive element-binding protein 5,
  • tax-responsive element-binding protein 5,
  • X-box-binding protein 1,

View in BioMuta


XBP1 is a transcription factor involved in hepatocyte growth, differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 also plays a role in activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) during endoplasmic reticulum stress. There is an XBP1 pseudogene on chromosome 5.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


XBP1 is also an estrogen-regulated gene and strongly correlates with estrogen receptor alpha (ERα) expression in breast cancers.

Performance Comment

XBP1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place January 20–21, 2016 in Bethesda, Maryland.

Announcement 08/26/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Wednesday-Thursday, January 20-21, 2016, on the NCI campus. More information will be available later this summer.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.