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XBP1

Basics

Aliases:
This biomarker is also known as:
  • XBP-1,
  • Tax-responsive element-binding protein 5,
  • TREB5,
  • XBP2,
  • X-box-binding protein 1,
  • X-box binding protein 1,
  • tax-responsive element-binding protein 5,

View in BioMuta

Description…

XBP1 is a transcription factor involved in hepatocyte growth, differentiation of plasma cells, immunoglobulin secretion, and the unfolded protein response (UPR). XBP1 regulates MHC class II genes by binding to a promoter element referred to as an X box. XBP1 also plays a role in activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE) during endoplasmic reticulum stress. There is an XBP1 pseudogene on chromosome 5.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: XBP1

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Breast

Attributes

Phase: Two
QA State: Under Review

Overview

XBP1 is also an estrogen-regulated gene and strongly correlates with estrogen receptor alpha (ERα) expression in breast cancers.

Performance Comment

XBP1 was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.