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This biomarker is also known as:
  • WW, C2 and coiled-coil domain containing 1,
  • HBeAg-binding protein 3,
  • Q8IX03,
  • protein KIBRA,
  • kidney and brain protein,
  • HBEBP3,
  • KIAA0869,
  • WW domain-containing protein 1,
  • WW and C2 domain containing 1,
  • protein WWC1,
  • Kidney and brain protein,
  • KIBRA,
  • HBEBP36,

View in BioMuta


WWC1, or KIBRA, is a cytoplasmic phosphoprotein. Expression has been detected in the brain, heart, colon and kidney, as well as mammary epithelial cells and breast cancer cell lines. WWC1 interacts with PRKC-zeta and dynein light chain-1. Alleles of this gene have been found that may be associated with memory performance. Three transcript variants encoding different isoforms have been found for the WWC1 gene.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: One
QA State: Under Review


No additional ovarian data available.

Performance Comment

WWC1 (KIBRA) was one of 50 tumor vasculature-associated genes with transmembrane or secreted protein products identified through expression profiling of ovarian cancer vascular cells. These 50 tumor vascular markers (TVMs) also had low or no expression in normal tissues. WWC1 (KIBRA) was not in the group of 13 selected for further validation.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.