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TP63

Basics

Aliases:
This biomarker is also known as:
  • OFC8,
  • SHFM4,
  • tumor protein p63,
  • Tumor protein p73-like,
  • NBP,
  • p73H,
  • B(p51B),
  • tumor protein 63,
  • Transformation-related protein 63,
  • Keratinocyte transcription factor KET,
  • EEC3,
  • p53CP,
  • B(p51A),
  • amplified in squamous cell carcinoma,
  • tumor protein p53-competing protein,
  • P63,
  • tumor protein p53-like,
  • TP73L,
  • tumor protein p63 deltaN isoform delta,
  • p40,
  • p51,
  • LMS,
  • CUSP,
  • RHS,
  • AIS,
  • KET,
  • p63,
  • Chronic ulcerative stomatitis protein,
  • TP53L,
  • p73L,
  • P73L,
  • P73H,

View in BioMuta

Description…

TP63 is a member of the p53 family of transcription factors. It acts as a sequence specific DNA binding transcriptional activator or repressor. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. TP63 may be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis.

Attributes

QA State: Under Review
Type: Gene
Short Name:
HGNC Name: TP63

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to http://grants.nih.gov /grants/guide/ pa-files/ PAR-15-289.html.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.