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TNFRSF1B

Basics

Aliases:
This biomarker is also known as:
  • TNF-R-II,
  • TNFri,
  • tumor necrosis factor receptor superfamily, member 1B,
  • TNFR80,
  • INN=Etanercept,
  • CD120b,
  • TNFr2,
  • Etanercept,
  • tumor necrosis factor binding protein 2,
  • TBPII,
  • TNFR1B,
  • p75,
  • TNFR-II,
  • soluble TNFR1B variant 1,
  • p75TNFR,
  • TNF-RII,
  • TNFBR,
  • CD_antigen=CD120b,
  • TNF-R75,
  • TNF-R2,
  • Tumor necrosis factor receptor 2,
  • TNFR2,
  • tumor necrosis factor beta receptor,
  • p80 TNF-alpha receptor,
  • Tumor necrosis factor receptor type II,
  • CD120b antigen,

View in BioMuta

Description…

TNFRSF1B, also known as TNFr2, a single-pass type I member of the TNF-receptor superfamily, forms a heterocomplex with TNF-receptor 1 that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Although the function of IAPs in TNF-receptor signalling is unknown, c-IAP1 is thought to potentiate TNF-induced apoptosis by the ubiquitination and degradation of TNF-receptor-associated factor 2, which mediates anti-apoptotic signals. Knockout studies in mice also suggest that TNFr2 plays a role in protecting neurons from apoptosis by stimulating antioxidative pathways.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: TNFRSF1B

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.