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This biomarker is also known as:
  • tumor necrosis factor-inducible gene 6 protein,
  • TNF-stimulated gene 6 protein,
  • TSG6,
  • TSG-6,
  • tumor necrosis factor, alpha-induced protein 6,
  • Tumor necrosis factor-inducible gene 6 protein,
  • Hyaluronate-binding protein,
  • TNF alpha-induced protein 6,
  • tumor necrosis factor-stimulated gene-6 protein,
  • P98066,

View in BioMuta


TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


TNFAIP6 (TSG6) localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

TNFAIP6 (TSG6) was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of TNFAIP6 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2016 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place March 14–15, 2016 in Bethesda, Maryland.

Announcement 11/05/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Monday-Tuesday, March 14-15, 2016, on the NCI campus. More information will be available later this autumn.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.