Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / TNFAIP6

TNFAIP6

Basics

Aliases:
This biomarker is also known as:
  • Hyaluronate-binding protein,
  • tumor necrosis factor, alpha-induced protein 6,
  • Tumor necrosis factor-inducible gene 6 protein,
  • TSG6,
  • P98066,
  • TNF-stimulated gene 6 protein,
  • tumor necrosis factor-stimulated gene-6 protein,
  • TSG-6,
  • tumor necrosis factor-inducible gene 6 protein,
  • TNF alpha-induced protein 6,

View in BioMuta

Description…

TNFAIP6 is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. It is possibly involved in cell-cell and cell-matrix interactions during inflammation and tumorigenesis. Enhanced levels of this protein are found in the synovial fluid of patients with osteoarthritis and rheumatoid arthritis.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: TNFAIP6

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

TNFAIP6 (TSG6) localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

TNFAIP6 (TSG6) was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of TNFAIP6 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to http://grants.nih.gov /grants/guide/ pa-files/ PAR-15-289.html.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.