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TMSB4X

Basics

Aliases:
This biomarker is also known as:
  • thymosin beta-4,
  • PTMB4,
  • Fx,
  • TMSB4,
  • thymosin, beta 4, X chromosome,
  • FX,
  • TB4X,
  • thymosin β4,
  • thymosin beta 4, X-linked,
  • prothymosin beta-4,
  • T beta-4,
  • THYB4,

View in BioMuta

Description…

TMSB4X, or thymosin beta-4, belongs to the thymosin beta family. It is an actin sequestering protein which plays an important role in the regulation of actin polymerization. TMSB4X binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. It is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: TMSB4X

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Lung

Attributes

Phase: Two
QA State: Under Review

Overview

Overexpression of thymosin beta-4 in tumors has been suggested to stimulate lung tumor metastasis by activating cell migration and angiogenesis. The gene expression of thymosin beta-4 was also significantly associated with metastasis in NSCLC patients and it was suggested as a prognostic parameter for NSCLC.

Performance Comment

Thymosin beta-4 belongs to a 9-member panel that provides a quantitative measure of the probability of having lung cancer that goes beyond the histological evaluation of preinvasive lesions. The identified members of the panel are TMSB4X (Thymosin beta-4), Ubiquitin, des-ubiquitin, ACBP, CSTA, Cytochrome C, and MIF.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

No associated publications found.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement