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TIMP1

Basics

Aliases:
This biomarker is also known as:
  • Tissue inhibitor of metalloproteinases 1,
  • TIMP-1,
  • EPO,
  • Collagenase inhibitor,
  • CLGI,
  • tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor),
  • HCI,
  • TIMP,
  • Fibroblast collagenase inhibitor,
  • Erythroid-potentiating activity,
  • metalloproteinase inhibitor 1,
  • TIMP metallopeptidase inhibitor 1,

View in BioMuta

Description…

The TIMP1 protein encoded by this TIMP gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of the TIMP1 gene is highly inducible in response to many cytokines and hormones. Metalloproteinase 1 is a stromal factor with multiple functions. Overexpression reduces pancreatic cancer cell implantation, growth, metastasis, and angiogenesis, while increasing tumor apoptosis, all without altering metallopeptidase 2 production.

Attributes

QA State: Under Review
Type: Protein
Short Name:
HGNC Name: TIMP1

Datasets

There are no datasets associated with this biomarker.

Organs

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Publications

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Resources

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place October 15–16, 2015 in Bethesda, Maryland.

Announcement 04/08/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held October 15-16, 2015 on the NCI campus. More information will be available later this summer.

Announcement