Aliases:This biomarker is also known as:
- Intestinal Trefoil Factor,
- Polypeptide P1.B,
- Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11,
- Trefoil Factor 3,
- Trefoil Factor 3 (Intestinal),
TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer.
Increased TFF3 transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.