This biomarker is also known as:
- Trefoil Factor 3 (Intestinal),
- Polypeptide P1.B,
- Trefoil Factor 3,
- Intestinal Trefoil Factor,
- Trefoil Factor 3, HITF, Human Intestinal Trefoil Factor11,
View in BioMuta
TFF3 is a member of the trefoil factor family. The trefoil factors are secreted peptides produced by normal intestinal mucosa, characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
Through gene expression profiling studies TFF3 mRNA has been found to be overexpressed in prostate cancer.
Increased TFF3 transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.
This biomarker is currently being annotated or is under review.
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Update: Pre-application webinar information now available.
The National Cancer Institute's Division of Cancer Prevention has released a new funding opportunity to solicit organ-specific applications for Biomarker Developmental Laboratories (BDLs), one of the four scientific units of the recently funded Early Detection Research Network (EDRN). The EDRN is a national infrastructure funded to discover, develop, and validate biomarkers for risk assessment, detection, and molecular diagnosis and prognosis of early cancer. BDLs are responsible for the discovery, development, characterization, and testing of new, or the refinement of existing, biomarkers and biomarker assays for risk assessment, detection, and molecular diagnosis and prognosis of cancers.
The existing BDLs are primarily focused on ovary and gastrointestinal cancers. The proposed BDLs (to be supported under this funding opportunity) should be focused on one or more of the following cancers: breast, prostate and other genitourinary organs, or lung. In addition, cancers with rapidly rising incidence rates, e.g., endometrial, hepatocellular, kidney, thyroid, oropharyngeal cancers, and/or cancers with unique etiology, e.g., mesothelioma, will be considered.
The newly funded units of the Early Detection Research Network will be announced later in April. Successful applicants have already been notified. Those researchers who were not successful during the last round of applications are encouraged to apply to this opportunity.