Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health www.cancer.gov

Navigation

Personal tools

You are here: Home / Biomarkers / ST14

ST14

Basics

Aliases:
This biomarker is also known as:
  • Q9Y5Y6,
  • EC 3.4.21,
  • MTSP1,
  • PRSS14,
  • OTTHUMP00000230931,
  • TMPRSS14,
  • tumor associated differentially expressed gene 15 protein,
  • suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin),
  • Membrane-type serine protease 1,
  • Prostamin,
  • TADG15,
  • Serine protease TADG-15,
  • SNC19,
  • OTTHUMP00000230932,
  • Tumor-associated differentially-expressed gene 15 protein,
  • prostamin,
  • Serine protease 14,
  • suppressor of tumorigenicity 14 protein,
  • MT-SP1,
  • HAI,
  • EC 3.4.21.109,
  • suppression of tumorigenicity 14 (colon carcinoma),
  • Matriptase,

View in BioMuta

Description…

ST14 protein is an epithelial-derived, integral membrane serine protease and is found to be activated by sphingosine 1-phosphate. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis.

Attributes

QA State: Curated
Type: Protein
Short Name:
HGNC Name: ST14

Datasets

There are no datasets associated with this biomarker.

Organs

The following organs have data associated with this biomarker…

Ovary

Attributes

Phase: Two
QA State: Under Review

Overview

ST14 localized to vascular-like structures in ovarian cancer but not in normal ovaries.

Performance Comment

ST14 was one of 13 genes out of 50 selected for further validation in PMID:21617380. Average expression of ST14 was significantly higher in epithelial ovarian cancer tumors than any other normal tissue tested.

Studies

This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at heather.kincaid@jpl.nasa.gov if you should have access to this biomarker.

Announcement 10/07/2014

EDRN Patient Advocates will host an EDRN Advocacy Educational Webinar, Biomarkers for Prostate Cancer Detection and Monitoring, on Monday, January 12th, 2015, at 1 p.m. EDT / 10 a.m. PDT. Registration is not required for this. Please click for more information.
Announcement 09/14/2014

Thank you to everyone who helped make the 9th EDRN Scientific Workshop a success. We look forward to seeing everyone at the 28th EDRN Steering Committee Meeting from March 31-April 2, 2015, in Atlanta, GA.