Aliases:This biomarker is also known as:
- Tumor-Associated Trypsin Inhibitor,
- Serine Protease Inhibitor, Kazal-Type 1,
- Serine Peptidase Inhibitor, Kazal Type 1,
- Pancreatic Secretory Trypsin Inhibitor,
- Serine Protease Inhibitor, Kazal Type 1,
SPINK1 is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. Its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Mutations in SPINK1 are associated with hereditary pancreatitis and tropical calcific pancreatitis.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
High levels of SPINK1 have been associated with a greater rate of prostate cancer recurrence.
Increased SPINK1 transcript expression can be a predictor of prostate cancer. A multiplexed model including seven biomarkers (AMACR, ERG, GOLPH2, PCA3, SPINK1, TFF3, TMPRSS2:ERG) outperforms serum PSA or PCA3 alone.