Aliases:This biomarker is also known as:
- Extracellular superoxide dismutase [Cu-Zn],
- superoxide dismutase 3, extracellular,
SOD3, a protein that is secreted into the extracellular space, forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. SOD3 is thought to protect the brain, lungs, and other tissues from oxidative stress. It protects the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen. SOD3 is a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. SOD3 is expressed in blood vessels, heart, lung, kidney and placenta. It is a major SOD isoenzyme in extracellular fluids such as plasma, lymph and synovial fluid.
|QA State:||Under Review|
There are no datasets associated with this biomarker.