Aliases:This biomarker is also known as:
- 56 kDa selenium-binding protein,
- selenium binding protein 1,
SELENBP1 belongs to the selenium-binding protein family. SELENBP1 may be involved in the sensing of reactive xenobiotics in the cytoplasm. It may also be involved in intra-Golgi protein transport. Selenium is an essential nutrient that exhibits potent anticarcinogenic properties, and deficiency of selenium may cause certain neurologic diseases. It has been proposed that the effects of selenium in preventing cancer and neurologic diseases may be mediated by selenium-binding proteins. The exact function of this gene is not known. SELENBP1 is highly expressed in liver, lung, colon, prostate, kidney and pancreas. In the brain, it present both in neurons and glia (at protein level). It has been shown to be down-regulated in lung adenocarcinoma, colorectal carcinoma and ovarian cancer, and two-fold up-regulated in brain and blood from schizophrenia patients.
|QA State:||Under Review|
There are no datasets associated with this biomarker.