Aliases:This biomarker is also known as:
- oncogene RHO H12,
- small GTP binding protein RhoA,
- Rho cDNA clone 12,
- Aplysia ras-related homolog 12,
- transforming protein RhoA,
- ras homolog family member A,
- rho cDNA clone 12,
- ras homolog gene family, member A,
RHOA is a member of the small GTPase superfamily. RHO family GTPases are involved in many basic cellular processes that influence cell proliferation, differentiation, motility, adhesion, survival, or secretion. RHOA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.
There are no datasets associated with this biomarker.
The following organs have data associated with this biomarker…
|QA State:||Under Review|
RHOA has been shown to be involved in hypoxia-inducible factor-mediated RHOA expression and signaling in breast cancer cells.
RHOA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.
- Stat6 cooperates with Sp1 in controlling breast cancer cell proliferation by modulating the expression of p21(Cip1/WAF1) and p27 (Kip1).
- Discovery and preliminary confirmation of novel early detection biomarkers for triple-negative breast cancer using preclinical plasma samples from the Women's Health Initiative observational study.
- Plasma biomarker profiles differ depending on breast cancer subtype but RANTES is consistently increased.