Skip to content. | Skip to navigation

National Cancer Institute U.S. National Institutes of Health


Personal tools

You are here: Home / Biomarkers / RHOA



This biomarker is also known as:
  • ras homolog gene family, member A,
  • ARH12,
  • Rho cDNA clone 12,
  • rho cDNA clone 12,
  • oncogene RHO H12,
  • h12,
  • ARHA,
  • transforming protein RhoA,
  • Rho12,
  • Aplysia ras-related homolog 12,
  • RHO12,
  • ras homolog family member A,
  • RHOH12,
  • small GTP binding protein RhoA,
  • RhoA,

View in BioMuta


RHOA is a member of the small GTPase superfamily. RHO family GTPases are involved in many basic cellular processes that influence cell proliferation, differentiation, motility, adhesion, survival, or secretion. RHOA regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers.


QA State: Curated
Type: Protein
Short Name:


There are no datasets associated with this biomarker.


The following organs have data associated with this biomarker…



Phase: Two
QA State: Under Review


RHOA has been shown to be involved in hypoxia-inducible factor-mediated RHOA expression and signaling in breast cancer cells.

Performance Comment

RHOA was one of numerous potential early detection biomarkers specific to triple-negative breast cancer in multiple pathways identified.


This biomarker is currently being annotated or is under review. You must be logged in or do not have permission to view any additional information. Contact Heather Kincaid at if you should have access to this biomarker.

2015 EDRN PI Orientation

The New and Continuing EDRN Principal Investigator Orientation will take place January 20–21, 2016 in Bethesda, Maryland.

Announcement 08/26/2015

Thank you to everyone who made the 29th EDRN Steering Committee Meeting a success. The orientation for new and continuing EDRN PIs will be held Wednesday-Thursday, January 20-21, 2016, on the NCI campus. More information will be available later this summer.

Announcement 06/30/2015

A funding opportunity for a new pancreatic cancer initiative, called The Pancreatic Cancer Detection Consortium (U01), has been released. For more information, please go to /grants/guide/ pa-files/ PAR-15-289.html.